Highspire is a borough in Dauphin County, Pennsylvania, United States. The population was 2,399 at the 2010 census, down from 2,720 at the 2000 census. It is part of the Harrisburg–Carlisle Metropolitan Statistical Area.
The American actor Don Keefer (1916–2014) was born in Highspire.
It is debated as to whether the town was named for the high spire of the church that could be seen from the Susquehanna River, or for the town in Bavaria where the original settlers and founders of the town were from. Either way, the town has a rich history of logging, the Pennsylvania canal system, candy, potato chips, whiskey, and hard working folks. It is a quaint little town nestled in between the towns of Steelton (home of the steel mill) and Middletown (where Harrisburg International Airport is located).
The Highspire High School was added to the National Register of Historic Places in 1990.
Highspire is located in southern Dauphin County at 40°12′27″N 76°47′5″W (40.207622, -76.784698), on the northeast bank of the Susquehanna River. Interstate 76, the Pennsylvania Turnpike, curves around the west and north sides of the borough, with indirect access from Exit 247 (Interstate 283). Pennsylvania Route 230 (Second Street) is the main road through the borough, leading northwest 7 miles (11 km) through Steelton to Harrisburg and southeast 3 miles (5 km) to Middletown and 11 miles (18 km) to Elizabethtown.
According to the United States Census Bureau, the borough has a total area of 0.74 square miles (1.92 km2), of which 0.72 square miles (1.86 km2) is land and 0.02 square miles (0.06 km2), or 2.96%, is water.
As of the census of 2000, there were 2,720 people, 1,279 households, and 689 families residing in the borough.