Lewisberry is a borough in York County, Pennsylvania, United States. The population was 362 at the 2010 census.
Lewisberry is located at 40°8′7″N 76°51′38″W (40.135300, -76.860504).
According to the United States Census Bureau, the borough has a total area of 0.1 square miles (0.26 km2), all of it land.
Ski Roundtop is located 3 miles (5 km) southwest of Lewisberry.
The lands in and around the borough of Lewisberry were under control of the Susquehannock people until the first Quaker settlements in the 1730s. These settlements were among the first Quaker settlements in America west of the Susquehanna River. Among the group of original titleholders along the small creek that would become known as Bennett Run were Ellis Lewis, Joseph Bennett, John Rankin, John Heald, and John Hall. At this time, the area that would become York County was still almost entirely populated by the Susquehannock Indians. Yet there are few recorded conflicts between these early settlers and the native population. In this area that would later become majority Pennsylvania German, the first and second waves of settlers were almost entirely English speakers and included the Kirks, Rankins, Huttons, Garetsons, Nebingers, Eppleys, Starrs, Fosters, Clines, Stromingers, Moores, Frankelbergers, Suttons, Wickershams, Prowells, Millers, and Hammonds. While most were Quakers, a significant minority were Anglicans.