Salisbury () is a city in and the county seat of Wicomico County, Maryland, United States, and the largest city in the state's Eastern Shore region. The population was 30,343 at the 2010 census. Salisbury is the principal city of the Salisbury, Maryland-Delaware Metropolitan Statistical Area. The city is the commercial hub of the Delmarva Peninsula, which was long devoted to agriculture and had a southern culture. It calls itself "The Comfortable Side of Coastal".
Salisbury's location at the head of Wicomico River was a major factor in growth. At first, it was a small colonial outpost set up by Lord Baltimore.
The Gillis-Grier House, Honeysuckle Lodge, Sen. William P. Jackson House, Pemberton Hall, Perry-Cooper House, Poplar Hill Mansion, Union Station, and F. Leonard Wailes Law Office are listed on the National Register of Historic Places.
Salisbury's location at the head of the Wicomico River was seen to be a convenient location for trading purposes. Due to the similar physical attributes as well as the nationality of Salisbury's founders, many historians believe that the name was inspired by the City of Salisbury, England, an ancient cathedral city.
Salisbury also had a role in the Civil War, as it served as a location where Union forces encamped in order to search for sympathizers from the South.