Zanesville is a city in and the county seat of Muskingum County, Ohio, United States. It is located 52 miles (84 km) east of Columbus. The population was 25,487 as of the 2010 census. Zanesville anchors the Zanesville Micropolitan Statistical Area (population 86,183) and is part of the Columbus-Marion-Zanesville Combined Statistical Area (population 2,508,498)
Zanesville was named after Ebenezer Zane (1747–1811), who had blazed Zane's Trace, a pioneer trail from Wheeling, Virginia (now in West Virginia) to Maysville, Kentucky through present-day Ohio. In 1797, he remitted land as payment to his son-in-law, John McIntire (1759–1815), at the point where Zane's Trace met the Muskingum River. With the assistance of Zane, McIntire platted the town, opened an inn and ferry by 1799. In 1801, Zanesville was officially renamed, formerly Westbourne, the chosen name for the settlement by Zane.
From 1810–1812, the city was the second state capital of Ohio. The National Road courses through Zanesville as U.S. Route 40. The city grew quickly in the 1820s–1850s.