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Laurel Run is a borough in Luzerne County, Pennsylvania, United States. The population was 500 at the 2010 census.
Laurel Run was incorporated as a borough in 1881. The borough is home to one of the oldest continuing motorsport events in Pennsylvania. Since 1906, the annual Giants Despair Hillclimb has challenged motorists to race uphill on a one-mile stretch of East Northampton Street.
In 1915, a mine fire started in the borough's Red Ash mine. The mine was excavated and the fire was declared extinguished in 1973. Approximately 166 homes, two grocery stores, a church, a school, and a lumberyard were razed and relocated through a program administered by the Appalachian Regional Commission.
Laurel Run is located at 41°13′2″N 75°50′29″W (41.217222, -75.841456).
According to the United States Census Bureau, the borough has a total area of 5.2 square miles (13.4 km2), all of it land. The borough is scarcely populated. Most of Laurel Run consists of mountainous forests. Laurel Run, a tributary of Mill Creek, flows through much of the borough.