Nanticoke is a city in Luzerne County, Pennsylvania, United States. As of the 2010 census, the population was 10,465, making it the third largest city in Luzerne County. It occupies 3.5 square miles of land. The city can be divided into several sections: Honey Pot (northwestern Nanticoke), Downtown (northern and central Nanticoke), and Hanover Section (southeastern Nanticoke). It was once an active coal mining community. Today, the 167-acre main campus of Luzerne County Community College is located within the city.
The name Nanticoke was derived from Nentego ("tidewater people"), an Algonquian-speaking Native American people who moved to the Wyoming Valley when their Maryland lands were spoiled for hunting by the European settlers. For quite some time, the tribe maintained a village in the valley before Europeans settled there. The nearby Nanticoke Creek, also named after the tribe, was once known as Muddy Run. However, its current name was appearing on maps as early as 1776.