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Cincinnati ( SIN-sih-NAT-ee) is a major city in the U.S. state of Ohio, and is the government seat of Hamilton County. Settled in 1788, the city is located at the northern side of the confluence of the Licking and Ohio rivers, the latter of which marks the state line with Kentucky. The city drives the Cincinnati–Middletown–Wilmington combined statistical area, which had a population of 2,172,191 in the 2010 census making it Ohio's largest metropolitan area. With a population of 301,301, Cincinnati is the third-largest city in Ohio and 65th in the United States. Its metropolitan area is the fastest growing economic power in the Midwestern United States based on increase of economic output and it is the 28th-largest metropolitan statistical area in the U.S. Cincinnati is also within a day's drive of 49.70% of the United States populace.

In the nineteenth century, Cincinnati was an American boomtown in the middle of the country. Throughout much of the 19th century, it was listed among the top 10 U.S. cities by population, surpassed only by New Orleans and the older, established settlements of the United States eastern seaboard, as well as being the sixth-biggest city for a period spanning 1840 until 1860. As Cincinnati was the first city founded after the American Revolution, as well as the first major inland city in the country, it is regarded as the first purely "American" city.

Cincinnati developed with fewer immigrants and less influence from Europe than East Coast cities in the same period. However, it received a significant number of German immigrants, who founded many of the city's cultural institutions. By the end of the 19th century, with the shift from steamboats to railroads drawing off freight shipping, trade patterns had altered and Cincinnati's growth slowed considerably. The city was surpassed in population by other inland cities, particularly Chicago, which developed based on strong commodity exploitation, economics, and the railroads, and St.